Finding ways to identify and prevent specific immune cells in diabetes
Identifying and preventing antigen specific T cells in diabetes
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11092898
This study is looking at how certain immune cells attack the insulin-making cells in people with Type 1 diabetes, and it aims to find ways to stop this from happening, which could lead to better treatments and screening for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11092898 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain immune cells, specifically CD4+ T cells, contribute to the destruction of insulin-producing beta cells in Type 1 diabetes (T1D). The team aims to identify hybrid peptides that may trigger these immune responses and explore methods to block their harmful effects. By studying these immune interactions in both human and mouse models, the researchers hope to develop new strategies for preventing T1D. Patients may benefit from improved screening and potential therapies that target these specific immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Type 1 diabetes or those recently diagnosed with the condition.
Not a fit: Patients with Type 2 diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for Type 1 diabetes and improved management of the disease.
How similar studies have performed: Previous studies have shown promise in identifying immune responses in diabetes, but this approach focusing on hybrid peptides is relatively novel.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FIFE, BRIAN T — UNIVERSITY OF MINNESOTA
- Study coordinator: FIFE, BRIAN T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diabetes, Autoimmune Diseases, autoimmune disorder, autoimmunity disease