Finding treatments for lung injuries caused by phosgene gas exposure
Identification and optimization of medical countermeasures for phosgene inhalation injuries
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10954052
This study is looking at how to better treat lung injuries caused by breathing in phosgene gas, which can happen in accidents or attacks, and it’s testing whether certain existing medications can help improve recovery and protect the lungs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10954052 on ClinicalTrials.gov |
What this research studies
This research focuses on developing effective treatments for lung injuries resulting from phosgene gas inhalation, which can occur in industrial accidents or as a result of terrorism. The study investigates the role of the renin-angiotensin-aldosterone system (RAAS) and soluble epoxide hydrolase (sEH) in lung injury and explores the potential of existing medications, such as ACE inhibitors, to improve survival and reduce lung damage. By using animal models, the researchers aim to identify the most effective therapeutic strategies to mitigate the harmful effects of phosgene exposure on the lungs.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals who have been exposed to phosgene gas, either in industrial settings or during terrorist attacks.
Not a fit: Patients who have not been exposed to phosgene gas or those with pre-existing severe lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates and recovery for patients suffering from phosgene inhalation injuries.
How similar studies have performed: Previous studies have shown promising results with similar approaches, particularly in the use of ACE inhibitors and sEH inhibitors for lung injury treatment.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ACHANTA, SATYANARAYANA — DUKE UNIVERSITY
- Study coordinator: ACHANTA, SATYANARAYANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome