Finding the best antibiotic treatments for critically ill children with multiple organ dysfunction syndrome.
Assessment of MODS and Personalized Exposures of Antibiotics
This study is looking at how to make antibiotic treatments better for critically ill children with multiple organ dysfunction syndrome by understanding how their bodies handle these medicines, so they can get the right amount at the right time to help them recover and survive.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10892661 on NIH RePORTER |
What this research studies
This research aims to improve antibiotic treatment strategies for critically ill children suffering from multiple organ dysfunction syndrome (MODS). By analyzing data from a large ongoing study, the researchers will assess how antibiotics are processed in the bodies of these children and how their immune status affects treatment. The goal is to develop personalized dosing strategies that ensure timely and effective antibiotic concentrations, which could significantly enhance survival rates. This research will involve 400 children already enrolled in the PARADIGM study, focusing on their unique responses to antibiotic therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill children aged 0-11 years who are diagnosed with multiple organ dysfunction syndrome.
Not a fit: Patients who are not critically ill or do not have multiple organ dysfunction syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibiotic treatments that improve survival rates for critically ill children with MODS.
How similar studies have performed: Previous research has shown promising results in personalizing antibiotic treatments for other populations, suggesting potential success for this novel approach in children with MODS.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Downes, Kevin James — Children's Hosp of Philadelphia
- Study coordinator: Downes, Kevin James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.