Finding new ways to improve T cell development for better immune therapies
Official title: Identification of Novel Epigenetic Regulators of lymphocyte Development
Funded at Boston Children's Hospital · NIH-10914259 · Data updated 2026-11-12
This study is looking at how certain factors affect the growth of T cells, which are important for our immune system, using special stem cells to find new ways to help create better T cells for treating diseases like cancer and autoimmune disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $154,138 |
| NIH project number | 5K99HL170075-02 |
| Project ID | NIH-10914259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from enhanced T cell therapies, such as cancer or autoimmune diseases.
✕Less likely to help
Patients with conditions unrelated to T cell function or those who do not require T cell-based therapies may not benefit from this research.
What this research studies
This research investigates how epigenetic factors influence the development of T cells, which are crucial for the immune system. By using human induced pluripotent stem cells (iPSCs), the team aims to identify novel mechanisms that regulate T cell differentiation. The approach includes screening small molecules during various stages of T cell development to discover new epigenetic regulators. This could lead to improved methods for generating functional T cells for therapies targeting diseases like cancer and autoimmune disorders.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of T cell therapies, providing better treatment options for patients with immune-related diseases.
How similar studies have gone: Other research has shown promise in using epigenetic modulation to improve T cell development, indicating that this approach may lead to significant advancements.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Jing, Ran — Boston Children's Hospital
- Study coordinator: Jing, Ran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.