Finding new ways to control the development and lifespan of neutrophils.
Official title: Identification of Novel Regulators for Neutrophil Development and Lifespan
Funded at Yale University · NIH-11120902 · Data updated 2026-11-12
This study is looking into how certain genes affect the life and development of neutrophils, which are important white blood cells that help fight infections and inflammation, to find new ways to treat conditions like lung injuries and bacterial infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 18, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $209,375 |
| NIH project number | 5R21AI175690-02 |
| Project ID | NIH-11120902 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions related to neutrophil dysfunction, such as acute lung injury or severe bacterial infections.
✕Less likely to help
Patients with stable, non-inflammatory conditions or those not affected by neutrophil-related issues may not benefit from this research.
What this research studies
This research investigates the biological mechanisms that regulate neutrophils, a type of white blood cell crucial for fighting infections and inflammation. By conducting a comprehensive genetic screen, the researchers aim to uncover novel regulators that influence how long neutrophils live and how they develop. Understanding these processes could lead to new treatments for conditions where neutrophils play a harmful role, such as in acute lung injury or bacterial infections. The study will involve laboratory experiments using biological models to explore these signaling pathways.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve immune responses and reduce tissue damage in inflammatory diseases.
How similar studies have gone: Previous research has shown promise in understanding neutrophil biology, but this approach aims to uncover novel mechanisms that have not been extensively studied.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Tang, Wenwen — Yale University
- Study coordinator: Tang, Wenwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.