Finding new treatment targets for a common childhood brain cancer.
Official title: Identification of BAIAP2 and CDC42 as potential therapeutic targets in SHH medulloblastoma
Funded at Georgetown University · NIH-10902644 · Data updated 2026-11-12
This study is looking at how two proteins, BAIAP2 and CDC42, might help medulloblastoma, a common brain tumor in kids, grow and spread, with the hope of finding new ways to treat this condition more safely and effectively.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 14, 2024 |
| Project end | September 13, 2027 |
| Funding year | 2024 |
| Award (this year) | $36,274 |
| NIH project number | 1F31CA291046-01 |
| Project ID | NIH-10902644 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with SHH medulloblastoma.
✕Less likely to help
Patients with other types of brain tumors or those outside the specified age range may not benefit from this research.
What this research studies
This research investigates the roles of two proteins, BAIAP2 and CDC42, in the development of medulloblastoma, the most common malignant brain tumor in children. By analyzing genetic data from tumor samples and comparing them to healthy brain cells, the researchers aim to understand how these proteins contribute to tumor growth and spread. The study utilizes advanced techniques like microarray and single-cell RNA sequencing to identify key genes involved in the disease. The ultimate goal is to discover new therapeutic targets that could lead to safer and more effective treatments for young patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve outcomes and reduce side effects for children with medulloblastoma.
How similar studies have gone: While the specific interaction of BAIAP2 and CDC42 in medulloblastoma is novel, similar approaches targeting protein interactions in other cancers have shown promising results.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Ruiz, Luz Clarita — Georgetown University
- Study coordinator: Ruiz, Luz Clarita
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.