Finding new RNA vaccines for Group A strep
An RNA vaccines systems approach to Group A streptococcus vaccine discovery
This project is working to find the best combination of ingredients for a new RNA vaccine to protect against Group A strep infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Imperial College of Science, Technology and Medicine NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project ID | NIH-10991334 on NIH RePORTER |
What this research studies
Group A strep infections cause significant health problems worldwide, and currently, there isn't a vaccine available. This project aims to develop a new type of vaccine using self-amplifying RNA (saRNA) technology. Researchers will study how adults naturally fight off Group A strep to understand what kind of protection children would need. They will then create and test different saRNA vaccine combinations to see which ones are most effective at preventing infections.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future vaccine trials would likely target children and adults susceptible to Group A strep infections.
Not a fit: Patients not at risk for Group A strep infections would not directly benefit from this specific vaccine development.
Why it matters
Potential benefit: If successful, this work could lead to a new vaccine that prevents Group A strep infections globally, potentially eradicating rheumatic heart disease and reducing severe infections.
How similar studies have performed: While there is no Group A strep vaccine in clinical use, RNA vaccine technology has shown success in other areas, making this a promising, yet still early-stage, approach for strep.
Where this research is happening
London, United Kingdom
- Imperial College of Science, Technology and Medicine — London, United Kingdom (Active)
Researchers
- Principal investigator: Sriskandan, Shiranee — Imperial College of Science, Technology and Medicine
- Study coordinator: Sriskandan, Shiranee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.