Finding new drugs to fight antibiotic-resistant bacteria
Official title: High Throughput Screening to Discover Bacterial DNA Gyrase Poisoning Inhibitors
Funded at Top Biosciences, LLC · NIH-10919287 · Data updated 2026-11-12
This study is looking for new drugs that can stop bacteria from growing by targeting a key enzyme they need, which could help create better treatments for infections, especially as many current antibiotics aren't working as well anymore.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Top Biosciences, LLC NIH-funded |
| Lab location | 1 site (Palmetto Bay, United States) |
| Project start | July 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $298,045 |
| NIH project number | 1R41TR005250-01 |
| Project ID | NIH-10919287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from bacterial infections that are resistant to current antibiotic treatments.
✕Less likely to help
Patients with infections caused by non-bacterial pathogens or those who do not have antibiotic-resistant infections may not benefit from this research.
What this research studies
This research focuses on developing a new method to identify drugs that can inhibit bacterial DNA gyrase, an essential enzyme for bacteria. By using high throughput screening, the researchers aim to test thousands of compounds quickly to find effective inhibitors that can combat antibiotic resistance. This approach is crucial as traditional antibiotics are becoming less effective due to resistance, and new solutions are urgently needed. The study targets the development of novel compounds that can damage bacterial DNA, potentially leading to new treatments for serious infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant bacterial infections.
How similar studies have gone: Previous research has shown success in developing antibiotics targeting bacterial DNA gyrase, but this specific high throughput screening approach is relatively novel.
Where this research is happening
-
Top Biosciences, LLC
Palmetto Bay, United States Active
Researchers
- Principal investigator: Leng, Fenfei — Top Biosciences, LLC
- Study coordinator: Leng, Fenfei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.