Finding hidden DNA switches that control TNF in immune cells
Discovery of novel regulatory territories in the TNF/LT locus
['FUNDING_OTHER'] · BOSTON CHILDREN'S HOSPITAL · NIH-11325839
Researchers are mapping small DNA regions that turn the immune signal TNF on or off in cells involved in autoimmune diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11325839 on ClinicalTrials.gov |
What this research studies
From my point of view, this project is trying to find the tiny DNA switches that control the TNF gene in immune cells like T cells and macrophages. Scientists will use modern sequencing tools to see which parts of the DNA are active in different cell types and when cells respond to infection or activation. They will use precise gene-editing in human cells and mouse models to test whether those regions actually change TNF levels. The aim is to point to new, more specific targets for future treatments that affect harmful TNF activity.
Who could benefit from this research
Good fit: People with TNF-driven autoimmune conditions such as rheumatoid arthritis, inflammatory bowel disease, or other inflammatory disorders could be the ultimate beneficiaries of therapies based on this work.
Not a fit: Patients whose conditions are not driven by TNF, or those needing immediate clinical treatment, are unlikely to gain direct benefit from this lab-focused research right now.
Why it matters
Potential benefit: May lead to new, more precise ways to reduce harmful TNF activity in autoimmune diseases.
How similar studies have performed: Existing anti-TNF drugs are effective for many autoimmune diseases, but using DNA regulatory mapping and CRISPR to find new regulatory targets is a newer lab-based approach with encouraging early results but not yet proven in patients.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDFELD, ANNE — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: GOLDFELD, ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases