Finding genetic markers that affect how people respond to certain bacterial infections.
Identification of Genetic Markers of Susceptibility to Intracellular Bacterial Infection Using the Collaborative Cross Mouse Model
This study is looking at how our genes affect how well our immune system fights off certain bacterial infections, like those caused by Rickettsia, using special mice that have different genetic backgrounds to help find new ways to treat these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geneva Foundation NIH-funded |
| Lab location | 1 site (Tacoma, UNITED STATES) |
| Project ID | NIH-10672355 on NIH RePORTER |
What this research studies
This research investigates how genetic differences influence the immune response to intracellular bacterial infections, specifically focusing on the Rickettsia pathogen. Using a unique mouse model with a wide range of genetic variations, researchers will analyze immune profiles and genetic markers that determine susceptibility to these infections. The study employs advanced techniques such as immunoprofiling and computational analyses to uncover the underlying mechanisms of immunity. By understanding these genetic factors, the research aims to pave the way for new therapeutic strategies against bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of severe reactions to bacterial infections or those with genetic predispositions to such infections.
Not a fit: Patients who do not have a genetic predisposition to bacterial infections or who have not experienced significant issues with such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for bacterial infections in humans.
How similar studies have performed: Previous research using similar genetic approaches in animal models has shown promise in identifying immune responses to various pathogens, suggesting a potential for success in this study as well.
Where this research is happening
Tacoma, UNITED STATES
- Geneva Foundation — Tacoma, United States (Active)
Researchers
- Principal investigator: Bergmannleitner, Elke — Geneva Foundation
- Study coordinator: Bergmannleitner, Elke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.