Finding genes that may help extend lifespan using fruit flies.
Official title: Evaluating a powerful genetic mapping framework to discover lifespan extension genes in Drosophila
Funded at University of Kansas Lawrence · NIH-11091607 · Data updated 2026-11-12
This study is looking at how certain genes in fruit flies might help them live longer, which could teach us more about aging and health as we get older.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $192,255 |
| NIH project number | 5R21AG086734-02 |
| Project ID | NIH-11091607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include older adults or individuals at risk for age-related diseases.
✕Less likely to help
Patients with acute or non-age-related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the genetic factors that influence lifespan by using the fruit fly, Drosophila melanogaster, as a model organism. By analyzing the genetic makeup of these flies, researchers aim to identify specific genes that contribute to longevity and the mechanisms of aging. The study employs advanced genetic mapping techniques to uncover these lifespan-extending genes, which could provide insights into age-related diseases and health maintenance as we age. This approach allows for controlled experiments that are difficult to conduct in humans due to various environmental and social factors.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or interventions that promote healthier aging and potentially extend lifespan in humans.
How similar studies have gone: Previous studies using Drosophila have shown promise in identifying genetic factors related to aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kansas Lawrence
Lawrence, United States Active
Researchers
- Principal investigator: Macdonald, Stuart John — University of Kansas Lawrence
- Study coordinator: Macdonald, Stuart John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.