Finding brain proteins linked to PTSD and alcohol use disorder

Who could benefit from this research

What this research studies

This research investigates the connection between brain proteins and the development of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD), particularly in U.S. Veterans. By analyzing genetic data from large studies, the research aims to identify specific proteins that may contribute to these disorders, which often occur together and complicate treatment. The study employs advanced genetic analysis techniques to pinpoint which genetic variations are truly responsible for these conditions, potentially leading to new treatment options. Patients may benefit from the development of targeted therapies that address the underlying biological mechanisms of PTSD and AUD.

Why it matters

Where this research is happening

• VA Northern California Health Care Sys
  Mather, United States Active

Researchers

• Principal investigator: Wingo, Aliza Pham — VA Northern California Health Care Sys
• Study coordinator: Wingo, Aliza Pham

Related research

Other NIH-funded projects on the same topics.

• Identifying brain proteins linked to PTSD and alcohol use disorder

  Researchers are studying brain proteins that may contribute to PTSD and alcohol use disorder in US veterans to find new ways to help people who struggle with both conditions.

  NIH research VA Northern California Health Care Sys · Mather, United States · NIH-11578051

• Genetic links between PTSD and Alcohol Use Disorder in teens and adults

  This grant studies how genetics and life experiences like childhood trauma shape the risk of PTSD and alcohol problems across adolescence into adulthood.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11401773

• Prediction of alcohol problems and PTSD after trauma in teens

  Teens who experience acute trauma are studied to see if certain biological signals can predict who might develop Alcohol Use Disorder or PTSD.

  NIH research University of Texas at Austin · Austin, United States · NIH-11391105

• Cognitive Processing Therapy plus Relapse Prevention for people with alcohol problems and PTSD

  This trial offers a combined Cognitive Processing Therapy and relapse-prevention program for adults with alcohol use disorder and PTSD to reduce drinking and PTSD symptoms.

  NIH research Texas A&m University · College Station, United States · NIH-11378367

• Genetic links between PTSD and alcohol problems from adolescence to adulthood

  This research looks at how genes and childhood trauma together relate to PTSD and alcohol problems from the teen years into adulthood.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11141804

• Using biomarkers to personalize treatment for alcohol use disorder and PTSD

  This study is looking at how certain biological markers can help customize treatments for people dealing with both alcohol use disorder and post-traumatic stress disorder, and it will test how well the medication topiramate works for them while considering their genetic factors.

  NIH research New York University School of Medicine · New York, United States · NIH-11141372

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.