Finding better ways to help the body recover from bone marrow failure
Official title: Improving Inflammation Resolution to Mitigate Acquired Bone Marrow Failure
Funded at Albany Medical College · NIH-11091480 · Data updated 2026-11-12
This study is looking at how to help the body heal from inflammation better, which could lead to improved treatments for people with severe aplastic anemia, especially older patients who often don’t respond well to current therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $493,796 |
| NIH project number | 5R01HL159411-03 |
| Project ID | NIH-11091480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults suffering from acquired bone marrow failure or severe aplastic anemia.
✕Less likely to help
Patients who are younger and respond well to current treatments may not benefit from this research.
What this research studies
This research focuses on improving the body's ability to resolve inflammation, which is crucial for treating acquired bone marrow failure. Current treatments, such as immunosuppressive therapies and bone marrow transplants, often fall short, especially in older patients. The study uses a mouse model that mimics human disease to explore how specialized pro-resolving mediators can enhance recovery from severe aplastic anemia. By promoting the resolution of inflammation rather than just suppressing it, the research aims to develop more effective therapies for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery outcomes for patients with bone marrow failure.
How similar studies have gone: Previous research has shown promise in using specialized pro-resolving mediators for similar inflammatory conditions, indicating potential for success in this approach.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Macnamara, Katherine C. — Albany Medical College
- Study coordinator: Macnamara, Katherine C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.