Faster TB tests for more people in high-burden countries
Official title: Rapid Research for Diagnostics Development in TB Network: Episode 2 (R2D2 TB Network II)
Funded at University of California, San Francisco · NIH-11607820 · Data updated 2026-11-12
A network-wide effort to identify and test new TB diagnostic tools so more patients can be diagnosed quickly and start treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 11, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $255,430 |
| NIH project number | 3R01AI190419-02S5 |
| Project ID | NIH-11607820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients at risk for TB in high-burden settings and health systems that need better diagnostic options.
✕Less likely to help
Patients in settings where TB diagnosis is already fast and accurate may see limited direct benefit.
What this research studies
This project connects developers of new TB tests with experienced clinical sites to evaluate and feedback performance in real-world settings. It focuses on selecting promising technologies that can meet WHO target profiles and fit use in diverse health systems. The aim is to close the TB diagnostic gap and improve outcomes for patients and their communities. The effort involves a collaborative team, industry partners, and clinical partners to move from discovery to practical, deployable diagnostics.
Why it matters
Potential benefit: If successful, patients in high-burden areas could be diagnosed faster and treated earlier, reducing transmission and mortality.
How similar studies have gone: Past studies have shown that multi-technology evaluation approaches can identify more accurate diagnostics for TB, though translation to widespread use remains challenging.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Nahid, Payam — University of California, San Francisco
- Study coordinator: Nahid, Payam
Related research
Other NIH-funded projects on the same topics.
-
How cancer cells use exosomes to evade the immune system
This study is looking at how cancer cells use tiny bubbles called exosomes to hide proteins that can keep your immune system from fighting the tumor, and by figuring this out, the researchers hope to help doctors understand why some people respond well to cancer treatments while others don’t, ultimately aiming to creat
-
Reducing harm from smoking using electronic cigarettes
This study is looking at whether using electronic cigarettes can be a safer option for people who smoke traditional cigarettes, by comparing the health effects and exposure to harmful substances between the two.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
Cutaneous opioid signals in skin inflammation
A mentor-identified clinician-researcher at UCSF is studying how natural skin opioids regulate itch and pain in inflammatory skin conditions like eczema and hidradenitis, with plans to map where these opioids come from and how they affect skin nerves.
-
Pooling international data to understand long-term bisphosphonate use and atypical femur fractures
This project combines large patient datasets from multiple countries to understand how long-term bisphosphonate use relates to rare hip and thigh bone fractures, helping doctors and patients make safer treatment choices.
-
Airway cell and immune cell talks in lung transplant failure
This grant tests how airway cells and immune cells interact to drive chronic rejection after lung transplant, with the goal of slowing or preventing scar-like damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.