NIH-funded research R01 grant

Family Spirit Strengths: A home visiting program to help parents and caregivers facing distress and substance use

Official title: Family Spirit Strengths: A home visiting strategy to support parents and caregivers with mental distress and substance misuse

Funded at Johns Hopkins University · NIH-11379493 · Data updated 2026-11-12

A home-visiting program designed for caregivers in Tribal communities to reduce depression, anxiety, and substance use and improve family wellbeing.

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Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University
NIH-funded
Lab location1 site (Baltimore, United States)
Project startAugust 15, 2023
Project endJune 30, 2028
Funding year2026
Award (this year)$571,061
NIH project number5R01DA057913-04
Project IDNIH-11379493 on NIH RePORTER

Who could benefit from this research

Could help

Caregivers of young children in Tribal communities who are at elevated risk for mental health or substance use disorders and who can participate in home-visiting sessions.

Less likely to help

Caregivers without elevated risk or those unable to participate in home visits may derive little direct benefit.

What this research studies

This project builds on a community-informed Family Spirit Strengths intervention delivered through home visits to mothers and primary caregivers at elevated risk for mental health and substance use issues. It uses a Hybrid Type I Design to test how well the program reduces depressive and anxiety symptoms and substance use, while also studying how it works in real-world Tribal settings. Participants are randomized to receive either the Family Spirit Strengths program or an active control nutrition support program, with outcomes assessed six months after enrollment. The research aims to understand who benefits most and why, by exploring factors that influence effectiveness and the mechanisms at play. If successful, the approach could offer a scalable, culturally resonant prevention option to disrupt intergenerational cycles of trauma in Indigenous communities.

Why it matters

Potential benefit: If successful, caregivers may experience fewer depression, anxiety, and substance-use symptoms and improved family well-being.

How similar studies have gone: Past work with Family Spirit and related family-based interventions have shown promise in improving caregiver wellbeing in similar populations.

Where this research is happening

  • Johns Hopkins University
    Baltimore, United States
    Active

Researchers

  • Principal investigator: Haroz, Emily — Johns Hopkins University
  • Study coordinator: Haroz, Emily

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.