Extracellular vesicles from hiPSC-derived M2 microglia-like cells to support stroke recovery
Official title: Extracellular Vesicles Secreted by Human Stem Cell-derived M2 Microglia-like Cells for Stroke
Funded at Florida State University · NIH-11422435 · Data updated 2026-11-12
A patient-focused look at a research project that aims to create tiny biological delivery packets from specialized human brain cells to help repair the brain after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 3, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $448,943 |
| NIH project number | 1R01NS143631-01A1 |
| Project ID | NIH-11422435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Excellent candidates are individuals who have experienced an ischemic stroke and might benefit from therapies promoting neural regeneration and reduced inflammation in the brain.
✕Less likely to help
Patients without access to advanced biologic therapies or those outside clinical development pathways may not directly benefit.
What this research studies
This project will engineer and bio-manufacture extracellular vesicles from hiPSC-derived M2 microglia-like cells to support neural regeneration after ischemic stroke. Researchers will study how these vesicles influence brain-region organoids to promote neurogenesis, synaptogenesis, and a more supportive brain environment. The work includes directing the production of vesicles with specific therapeutic cargo and testing their effects on brain tissue models to reduce inflammation and protect neurons.
Why it matters
Potential benefit: If successful, the approach could lead to new therapies that support brain repair after stroke by delivering protective signals directly to neural tissue.
How similar studies have gone: Previous work has shown that microglia-derived signals and extracellular vesicles can influence neural environments, supporting the potential of this approach.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Li, Yan — Florida State University
- Study coordinator: Li, Yan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.