Exploring what drives cancer growth and how tumors interact with their surroundings
Deep exploration of drivers, evolution, and microenvironment toward discovering principal themes in cancer
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11176339
This project uses advanced genetic and single-cell tools to learn how tumors grow, change, and interact with the immune system in people with advanced cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11176339 on ClinicalTrials.gov |
What this research studies
This project will combine large-scale genome and RNA sequencing with single-cell and spatial genomics to map cancer cells and their neighborhood in tumors from people with advanced cancer. Researchers will use powerful computational tools to link inherited and tumor-specific genetic changes to tumor cell types, evolution, and the surrounding immune and support cells. The team will work with large, well-curated patient tumor datasets and NCI network partners to integrate these data. The goal is to reveal patterns that explain treatment resistance and suggest better, more personalized approaches.
Who could benefit from this research
Good fit: Adults with advanced or metastatic tumors who can provide tumor tissue samples or agree to share genomic and clinical data would be the best fit.
Not a fit: Patients without available tumor tissue, those with early-stage disease not covered by the cohorts, or those with conditions outside the study focus may not directly benefit.
Why it matters
Potential benefit: If successful, the work could point to new diagnostic markers and treatment targets that help personalize care for people with cancer.
How similar studies have performed: Large-scale genomic and single-cell studies have already identified important cancer drivers and immune interactions, but combining these approaches across many patients to reveal common themes is still emerging.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DING, LI — WASHINGTON UNIVERSITY
- Study coordinator: DING, LI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer, Cancer Center, Cancer Patient