Exploring the role of tiny proteins in the immune system
Official title: Unraveling microprotein biology with an evolutionary-immunological framework
Funded at University of Pittsburgh at Pittsburgh · NIH-10925317 · Data updated 2026-11-12
This study is looking at tiny proteins called microproteins to see how they work with our immune system, which could help us find new ways to treat autoimmune diseases and other health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 8, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,485,481 |
| NIH project number | 5R01AT012826-02 |
| Project ID | NIH-10925317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases or those interested in the genetic factors influencing immune responses.
✕Less likely to help
Patients with conditions unrelated to the immune system or those not affected by autoimmune diseases may not receive direct benefits from this research.
What this research studies
This research investigates the function of microproteins, which are small proteins that have been largely overlooked in genetic studies. By examining how these microproteins evolve and their interactions with the immune system, the research aims to uncover their physiological relevance and potential roles in immune responses. The approach combines evolutionary biology with immunology to understand how these proteins may help the body respond to pathogens. Patients may benefit from insights gained about microproteins that could lead to new treatments for autoimmune diseases and other conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for autoimmune diseases and enhance our understanding of immune responses.
How similar studies have gone: While the exploration of microproteins is a relatively novel area, previous research has shown that understanding protein evolution can lead to significant advancements in immunology.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Carvunis, Anne-Ruxandra — University of Pittsburgh at Pittsburgh
- Study coordinator: Carvunis, Anne-Ruxandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.