Exploring the role of BNP in cardiovascular disease beyond its use as a biomarker
Official title: BNP not just a biomarker of cardiovascular disease
Funded at Texas A&m University Health Science Ctr · NIH-11030796 · Data updated 2026-11-12
This study is looking at how a substance called B-type natriuretic peptide (BNP) can help doctors understand heart failure better and see if it plays a role in making heart problems worse, so if you're dealing with heart issues, you might have a chance to participate and help us learn more about your condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | February 15, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $463,480 |
| NIH project number | 5R01HL167767-02 |
| Project ID | NIH-11030796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with heart failure or acute coronary syndrome who are being monitored for BNP levels.
✕Less likely to help
Patients with non-cardiovascular conditions or those not exhibiting elevated BNP levels may not benefit from this research.
What this research studies
This research investigates the dual role of B-type natriuretic peptide (BNP) in cardiovascular disease, focusing on its function as both a diagnostic biomarker and a potential contributor to disease progression. The study will analyze how BNP levels correlate with heart failure severity and the risk of adverse cardiovascular events, such as myocardial infarction. By examining the effects of BNP on thrombus formation and platelet aggregation in both animal models and human subjects, the research aims to uncover new insights into the mechanisms of cardiovascular disease. Patients may be involved in trials assessing BNP's impact on their condition and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cardiovascular diseases, potentially enhancing treatment strategies for patients.
How similar studies have gone: Preliminary studies have shown promising results regarding BNP's role in thrombus formation, suggesting that this research builds on existing findings rather than exploring a completely novel area.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Li, Zhenyu — Texas A&m University Health Science Ctr
- Study coordinator: Li, Zhenyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.