Exploring the molecular network in the brain related to mental health
Investigation of the Synaptic Molecular Network using Multiplexed Imaging
This study is looking at how proteins in the brain work together to help with learning and memory, especially when things go wrong in mental health conditions, and it aims to see how different antidepressants can change these protein interactions to help create better treatments for people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10651858 on NIH RePORTER |
What this research studies
This research investigates the complex interactions of proteins in the brain that are crucial for learning and memory, particularly focusing on how these interactions are disrupted in various mental health disorders. Using a cutting-edge imaging technique called PRISM, the study aims to visualize and analyze the behavior of proteins at the synapse level, which is where neurons communicate. By examining how different antidepressants affect these protein networks, the research seeks to improve our understanding of the molecular causes of psychiatric conditions and enhance the development of more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with psychiatric disorders, particularly those who have not responded well to existing antidepressant treatments.
Not a fit: Patients with non-psychiatric conditions or those who are not currently experiencing mental health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted antidepressant therapies that are more effective for patients with mental health disorders.
How similar studies have performed: Previous research has shown promising results using similar multiplexed imaging techniques to understand brain function and the effects of psychiatric medications.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Bathe, Mark — Massachusetts Institute of Technology
- Study coordinator: Bathe, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.