Exploring RNA's Role in Neurologic Diseases
Official title: Applying RNA Logic in Space and Time to Neurologic Disease
Funded at Rockefeller University · NIH-11139243 · Data updated 2026-11-12
This study is exploring how RNA works in the brain to find new ways to treat brain diseases, helping researchers understand the genetic causes and how different brain cells are involved, so they can develop better treatments for people affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2033 |
| Funding year | 2025 |
| Award (this year) | $1,232,909 |
| NIH project number | 1R35NS143059-01 |
| Project ID | NIH-11139243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurologic diseases or disorders that may have genetic components.
✕Less likely to help
Patients with neurologic conditions that are purely environmental or non-genetic in nature may not benefit from this research.
What this research studies
This research investigates how RNA functions in the brain to uncover new treatment targets for neurologic diseases. By combining insights from modern molecular biology with clinical neurology, the project aims to identify the genetic causes of brain disorders and how different cell types contribute to these conditions. The approach includes developing new techniques to study RNA regulation in neurons, which are complex and dynamic cells. Ultimately, the goal is to enhance our understanding of human neurologic diseases through innovative model systems.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new therapeutic targets for treating neurologic diseases.
How similar studies have gone: Other research has shown promise in using RNA-based approaches to understand and treat neurologic diseases, indicating that this methodology has potential for success.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Darnell, Robert B — Rockefeller University
- Study coordinator: Darnell, Robert B
Related research
Other NIH-funded projects on the same topics.
-
How cells organize into organized tissues to form organs
Researchers are studying how human-like cells in a lab can self-organize within a scaffold to form orderly tissue patterns, which could illuminate how organs such as skin and bones develop.
-
Modeling Ataxia Telangiectasia in a human stem cell model of Purkinje cells
Researchers are creating a patient-derived, human cell model of Purkinje cells to understand why this brain disease causes cerebellar degeneration in people with Ataxia Telangiectasia.
-
Centers studying how cancer spreads through the body
A multi-institutional project at Rockefeller University is exploring how nerves, blood vessels, lymphatics, immune cells, and metabolites influence the spread of cancer to help identify new ways to stop metastasis.
-
Understanding how mycobacterial transcription works to guide better TB drugs
Researchers will study how the RNA polymerase of Mycobacterium tuberculosis and related bacteria start, pause, and finish copying genetic information, with the goal of informing new antibiotic strategies against TB.
-
How chromosomes stay true when cells divide in cancer research
Researchers are studying how chromosomes are accurately copied and distributed during cell division to understand and potentially prevent cancer.
-
Marmoset model of Huntington's disease shows how symptoms relate to brain and behavior
A researcher at a top university is studying how Huntington's disease affects brain signals and behavior in marmosets to better understand the human condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.