Exploring proteins that control inflammation in autoimmune conditions
Chemoproteomic-Enabled Strategy to Study SLC Transporter Roles in Inflammation
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11121734
This work aims to understand how certain proteins contribute to inflammation in autoimmune diseases, hoping to find new ways to calm overactive immune responses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11121734 on ClinicalTrials.gov |
What this research studies
The immune system usually protects us, but sometimes it can go wrong and cause autoimmune diseases. This project looks at how specific immune sensors and inflammatory signals, like those seen in lupus and Crohn's disease, contribute to these conditions. Researchers are particularly interested in a protein called SLC15A4, which has shown promise in reducing disease in mouse models of lupus. By using advanced chemical tools, the team hopes to discover new ways to block these harmful inflammatory signals and develop potential treatments.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals living with autoimmune diseases, such as lupus and Crohn's disease, in the future.
Not a fit: Patients without autoimmune conditions or those whose conditions are not driven by the specific inflammatory pathways being investigated may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that specifically target and reduce the inflammation seen in autoimmune diseases.
How similar studies have performed: Previous studies in mouse models have shown that targeting the SLC15A4 protein can significantly reduce disease symptoms, suggesting a promising avenue for further investigation.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARKER, CHRISTOPHER G — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: PARKER, CHRISTOPHER G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases