Exploring how VGLL3 affects autoimmune diseases more in women
Understanding the immunometabolic mechanism of VGLL3 mediating female-biased autoimmunity
['FUNDING_R01'] · MICHIGAN STATE UNIVERSITY · NIH-11063283
This study is looking at a molecule called VGLL3, which works differently in women, to see how it might affect the body's response to stress and contribute to autoimmune diseases, with the goal of finding new ways to help prevent and treat these conditions that often impact women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-11063283 on ClinicalTrials.gov |
What this research studies
This research investigates the role of VGLL3, a molecule that is more active in females, in the development of autoimmune diseases. It aims to understand how VGLL3 influences the body's response to metabolic stress and how this may lead to autoimmune conditions. The study will explore the cellular mechanisms involved and the impact of VGLL3 on immune responses in female patients. By uncovering these processes, the research seeks to identify new ways to prevent and treat autoimmune diseases that disproportionately affect women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are at risk for or currently suffering from autoimmune diseases.
Not a fit: Patients who do not identify as female or those with autoimmune diseases unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies for autoimmune diseases that are more prevalent in women.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIANG, YUN — MICHIGAN STATE UNIVERSITY
- Study coordinator: LIANG, YUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder