Exploring how type III interferons regulate immune responses
Official title: Identification of novel type III IFN regulatory pathways
Funded at Ohio State University · NIH-10897271 · Data updated 2026-11-12
This study is looking at how a special type of protein called type III interferons helps protect our cells from damage during viral infections and stress, especially in the lining of our organs, and it hopes to find ways to use this knowledge to improve healing and reduce inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5R35GM150806-02 |
| Project ID | NIH-10897271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing viral infections or conditions associated with cellular stress that may benefit from enhanced immune responses.
✕Less likely to help
Patients with conditions unrelated to viral infections or cellular stress may not receive any benefit from this research.
What this research studies
This research investigates the role of type III interferons (IFNλ) in maintaining cellular integrity and preventing tissue damage during viral infections and cellular stress. It aims to understand the specific pathways and mechanisms through which these interferons operate, particularly in epithelial cells, and how they can provide antiviral protection with minimal inflammation. By employing a multidisciplinary approach, the research will analyze the signaling events and cell identity that influence the effectiveness of IFNλ responses. This could lead to new insights into managing inflammatory responses and improving tissue repair.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions involving excessive inflammation and tissue damage, enhancing patient recovery and health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the roles of type I and type III interferons in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Forero, Adriana — Ohio State University
- Study coordinator: Forero, Adriana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.