Exploring how the RNase L pathway responds to viral infections
Official title: Understanding the OAS/RNase L pathway during pathogenic viral infections
Funded at University of Florida · NIH-10927306 · Data updated 2026-11-12
This study is looking at how a part of our immune system called the RNase L pathway helps fight off viruses like COVID-19 and dengue, with the goal of finding ways to boost our body's ability to respond to these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $483,000 |
| NIH project number | 5R35GM151249-02 |
| Project ID | NIH-10927306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals affected by viral infections such as COVID-19 or dengue fever.
✕Less likely to help
Patients with non-viral infections or those not affected by the studied viruses may not benefit from this research.
What this research studies
This research investigates the RNase L pathway, a crucial part of the body's antiviral defense, to understand how it interacts with pathogenic viruses like COVID-19 and dengue. The team will explore how RNase L affects the translation of viral and host mRNAs, aiming to uncover mechanisms that allow viruses to evade the immune response. By studying the degradation of cellular mRNAs and the preservation of antiviral proteins, the research seeks to clarify how the body can better respond to viral infections. This could lead to new strategies for enhancing antiviral responses in patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for viral infections, enhancing the body's ability to fight off diseases like COVID-19 and dengue.
How similar studies have gone: Previous research has shown promising results in understanding antiviral pathways, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Burke, James M — University of Florida
- Study coordinator: Burke, James M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.