Exploring how specific immune cells respond to metabolites in the body.
Uncovering the hidden universe of metabolite-specific T lymphocytes,using human multiorgan microphysiological systems.
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10847435
This study is looking at how special immune cells called T lymphocytes interact with substances in the body to better understand diseases like inflammatory bowel disease and autoimmune hepatitis, which could help find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10847435 on ClinicalTrials.gov |
What this research studies
This research investigates the role of unconventional T lymphocytes in autoimmune and metabolic diseases using advanced human microphysiological models. By examining how these immune cells interact with metabolites, the study aims to uncover the underlying mechanisms of complex diseases like inflammatory bowel disease and autoimmune hepatitis. The approach involves creating donor-matched tissue models to simulate human physiology and employing systems biology tools for detailed analysis. This could lead to a better understanding of how these immune responses contribute to disease progression and potential treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases such as inflammatory bowel disease, autoimmune hepatitis, or type 1 diabetes.
Not a fit: Patients with non-autoimmune related conditions or those not affected by metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for patients suffering from autoimmune and metabolic disorders.
How similar studies have performed: Previous research has shown promise in understanding immune responses in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRAPECAR, MARTIN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: TRAPECAR, MARTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, Brittle Diabetes Mellitus