Exploring how RNA modifications influence gene regulation
Official title: Determining the role of RNA abasic sites in gene regulation
Funded at Brown University · NIH-11232265 · Data updated 2026-11-12
This study is looking at special changes in RNA that can affect how genes work, and it's for anyone interested in understanding how these changes might influence important genes like APOE and overall cell function.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $47,850 |
| NIH project number | 7R21ES034919-03 |
| Project ID | NIH-11232265 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to gene regulation or expression abnormalities.
✕Less likely to help
Patients with no known issues related to gene regulation or RNA modifications may not benefit from this research.
What this research studies
This research investigates the role of RNA abasic sites, which are modifications in RNA that can affect gene expression. The study focuses on understanding how these sites are formed, their precursors, and their functions in stabilizing RNA and regulating transcription. By examining the interactions between RNA and proteins, the research aims to uncover the mechanisms by which RNA abasic sites influence the expression of important genes, such as APOE. This could provide insights into the broader implications of RNA modifications in cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation mechanisms, potentially impacting treatments for diseases linked to gene expression.
How similar studies have gone: While RNA modifications are a relatively novel area of study, previous research on DNA abasic sites has shown significant success in understanding gene regulation, suggesting potential for similar breakthroughs in RNA.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Cheung, Vivian G — Brown University
- Study coordinator: Cheung, Vivian G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.