Exploring how RNA interference affects gene regulation in worms
Official title: Investigation of RNA interference and related gene regulatory mechanisms
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10842794 · Data updated 2026-11-12
This study is looking at how tiny molecules in worms help control genes and protect against harmful information, which could help us learn more about genetic diseases and treatments that might benefit patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $115,156 |
| NIH project number | 1R35GM153442-01 |
| Project ID | NIH-10842794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or those interested in the mechanisms of gene regulation.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or those not affected by genetic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms of RNA interference and gene regulation using the model organism C. elegans, a type of worm. By examining how cells differentiate between safe and potentially harmful genetic information, the study aims to uncover the roles of various proteins and small RNA molecules in gene expression. The research will utilize advanced genetic techniques to analyze how these processes are inherited across generations, potentially revealing insights into fundamental biological functions. Patients may benefit from understanding these mechanisms as they relate to genetic diseases and therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic disorders by enhancing our understanding of gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding RNA interference and gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Mello, Craig C — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Mello, Craig C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.