Exploring how REV-ERB affects Th17 cell function in autoimmune diseases
Official title: Investigating the link between REV-ERB and HIF-1a in Th17 cell function
Funded at Auburn University at Auburn · NIH-10886128 · Data updated 2026-11-12
This study is looking at how a protein called REV-ERB affects a type of immune cell linked to autoimmune diseases, like rheumatoid arthritis and Type I diabetes, to help find new treatments that could benefit patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project start | July 11, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $71,412 |
| NIH project number | 5R03AI177835-02 |
| Project ID | NIH-10886128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune diseases such as rheumatoid arthritis, Type I diabetes, or multiple sclerosis.
✕Less likely to help
Patients with autoimmune diseases that do not involve Th17 cell dysregulation may not benefit from this research.
What this research studies
This research investigates the role of REV-ERB in regulating Th17 cells, which are crucial in the immune response and are linked to various autoimmune diseases. By understanding how REV-ERB influences the activation and differentiation of these cells, the research aims to identify new therapeutic targets for conditions like rheumatoid arthritis and Type I diabetes. The study will involve laboratory assays to analyze cellular mechanisms and cytokine production. Patients may benefit from potential new treatments that arise from this understanding.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and affordable therapies for autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in targeting Th17 cells for autoimmune disease therapies, indicating that this approach has potential for success.
Where this research is happening
-
Auburn University at Auburn
Auburn, United States Active
Researchers
- Principal investigator: Griffett, Kristine — Auburn University at Auburn
- Study coordinator: Griffett, Kristine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.