Exploring how proteins communicate in cells through chemical modifications
Official title: Chemoenzymatic Protein Semisynthesis Approaches Toward Cell Signaling Enzymes
Funded at Ohio State University · NIH-10915698 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells are changed by chemical signals, which can help us understand diseases like cancer and diabetes better, so we can find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5R35GM151124-02 |
| Project ID | NIH-10915698 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions influenced by cell signaling abnormalities, including certain cancers and metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to cell signaling or those who do not have any of the targeted diseases may not receive direct benefits from this research.
What this research studies
This research investigates the role of protein phosphorylation in cellular processes, focusing on how specific signaling enzymes are regulated by chemical modifications. By using advanced protein semisynthesis techniques, the study aims to create precise models of key enzymes involved in cell signaling, such as S6K1 and PP2A. This approach allows researchers to better understand the mechanisms that control these enzymes and their impact on diseases like cancer and diabetes. Patients may benefit from insights gained into how these signaling pathways can be targeted for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively target diseases related to cell signaling dysfunction, such as cancer and diabetes.
How similar studies have gone: Previous research has shown promise in using protein semisynthesis to understand cell signaling, indicating that this approach has potential for success.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Chu, Nam Ky — Ohio State University
- Study coordinator: Chu, Nam Ky
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.