NIH-funded research R01 grant

Exploring how powered prosthetic devices affect walking in K2-level amputees

Official title: Understanding how Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

Funded at Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · NIH-10873073 · Data updated 2026-11-12

This study is looking at how lightweight powered knee and ankle prosthetics can help people with a leg amputation walk better, especially when it comes to tasks like climbing stairs and getting up from a chair, and it’s for individuals who currently use basic prosthetics.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionRehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
NIH-funded
Lab location1 site (Chicago, United States)
Project startJuly 1, 2023
Project endJune 30, 2028
Funding year2024
Award (this year)$672,208
NIH project number5R01HD108554-02
Project IDNIH-10873073 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals with a unilateral transfemoral amputation who are classified as K2-level ambulators and currently use a passive prosthesis.

Less likely to help

Patients who do not have a transfemoral amputation or those classified as K3 or K4 ambulators may not benefit from this research.

What this research studies

This research investigates the impact of lightweight powered knee and ankle prosthetics on the walking ability of individuals with a unilateral transfemoral amputation classified as K2-level ambulators. The study aims to evaluate how these advanced devices can improve mobility tasks such as climbing stairs and transitioning from sitting to standing, while also assessing the metabolic costs associated with their use. By recruiting 20 participants who currently use passive prostheses, the research will analyze the benefits and trade-offs of using powered components in terms of gait biomechanics and functional mobility.

Why it matters

Potential benefit: If successful, this research could enhance the mobility and quality of life for K2-level amputees by providing them with more effective prosthetic options.

How similar studies have gone: Previous research has shown that powered prosthetic devices can significantly improve mobility in higher-level amputees, suggesting potential benefits for K2-level users as well.

Where this research is happening

  • Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
    Chicago, United States
    Active

Researchers

  • Principal investigator: Hargrove, Levi John — Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
  • Study coordinator: Hargrove, Levi John

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.