Exploring how new enhancers affect antibody diversity
Official title: Impact of novel enhancers on Igh repertoire diversity
Funded at University of Illinois at Chicago · NIH-10925311 · Data updated 2026-11-12
This study is looking at how certain DNA elements help B cells, which are important for making antibodies, develop properly, and it aims to find ways to improve immune responses for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | September 8, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $602,058 |
| NIH project number | 5R01AI177507-02 |
| Project ID | NIH-10925311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions affecting B cell function or antibody production.
✕Less likely to help
Patients with conditions unrelated to B cell development or antibody production may not receive any benefit from this research.
What this research studies
This research investigates the role of novel enhancers in the development of B cells, which are crucial for producing antibodies. By using advanced techniques to analyze the three-dimensional structure of the immunoglobulin heavy chain (Igh) locus, the study aims to understand how these enhancers influence the diversity of antibody repertoires. The research focuses on the interactions between DNA elements that facilitate the rearrangement of antibody genes during early B cell development in the bone marrow. Patients may benefit from insights gained into how B cell development can be optimized for better immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients, potentially benefiting those with immune deficiencies or related conditions.
How similar studies have gone: Other research has shown promising results in understanding the genetic mechanisms of B cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kenter, Amy L — University of Illinois at Chicago
- Study coordinator: Kenter, Amy L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.