Exploring how immune genes and inflammation affect schizophrenia
Official title: Investigating the role of immune genes and inflammatory biomarkers in schizophrenia heterogeneity
Funded at Vanderbilt University · NIH-11000808 · Data updated 2026-11-12
This study is looking at how certain immune genes and inflammation might be connected to schizophrenia, helping us understand if inflammation plays a role in causing the condition or if it happens because of it, all to improve care for people with schizophrenia.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $53,351 |
| NIH project number | 5F30MH132165-03 |
| Project ID | NIH-11000808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia or related disorders who are willing to participate in longitudinal assessments.
✕Less likely to help
Patients with schizophrenia who are not interested in participating in research or those with other unrelated psychiatric conditions may not benefit from this research.
What this research studies
This research investigates the relationship between immune genes, inflammatory biomarkers, and schizophrenia to better understand the biological mechanisms behind this complex condition. By utilizing a large biobank linked to electronic health records, the study will analyze how levels of immune biomarkers change over time in relation to schizophrenia diagnoses. It aims to determine whether inflammation contributes to the development of schizophrenia or is a result of the disorder, and how these factors may predict clinical outcomes for patients. This approach combines genetic analysis with clinical data to provide a comprehensive view of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with schizophrenia by identifying specific immune-related factors that influence the condition.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune factors in schizophrenia, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Lake, Allison Michelle — Vanderbilt University
- Study coordinator: Lake, Allison Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.