Exploring how genes and environmental factors interact in brain diseases
Defining gene-by-environment interactions using multiplex single-cell genomics
This study is looking at how changes in our genes can influence how brain cells react to things like stress and toxins, which could help us understand diseases like Alzheimer's better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11110037 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic changes affect the way brain cells respond to various environmental factors, such as stress and toxins. Using advanced techniques like CRISPR and single-cell genomics, the team will analyze thousands of unique gene and exposure combinations at the individual cell level. This approach aims to uncover the complex interactions that may contribute to neurobiological diseases, particularly Alzheimer's disease. By developing a high-throughput platform, the research seeks to provide insights that could lead to more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Alzheimer's disease or those experiencing early symptoms of neurodegeneration.
Not a fit: Patients with neurobiological conditions unrelated to genetic factors or environmental interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and other neurobiological disorders.
How similar studies have performed: Previous research using CRISPR and single-cell genomics has shown promise in understanding gene-environment interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Mcfaline-Figueroa, Jose Luis — Columbia Univ New York Morningside
- Study coordinator: Mcfaline-Figueroa, Jose Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.