Exploring how genes and environmental factors interact in brain diseases.
Defining gene-by-environment interactions using multiplex single-cell genomics
This study is looking at how changes in our genes can influence how brain cells react to things like stress and toxins, which could help us understand more about diseases like Alzheimer's and how they might be linked to our environment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10873757 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic changes affect the way brain cells respond to various environmental factors, such as stress and toxins. By using advanced techniques like CRISPR and single-cell genomics, the team aims to create a platform that can analyze thousands of different gene-environment combinations at the individual cell level. This approach will help identify specific interactions that may contribute to neurobiological diseases, particularly Alzheimer's disease. Patients may benefit from insights gained about how their genetic makeup interacts with environmental exposures.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with non-neurodegenerative conditions or those without genetic predispositions to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for neurodegenerative diseases by identifying specific gene-environment interactions.
How similar studies have performed: Previous research has shown promising results in understanding gene-environment interactions in other diseases, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Mcfaline-Figueroa, Jose Luis — Columbia Univ New York Morningside
- Study coordinator: Mcfaline-Figueroa, Jose Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.