Exploring how gene splicing affects cell function and organization
Official title: When alternative splicing meets cytoskeleton organization, local translation, and transcription regulation
Funded at Univ of North Carolina Chapel Hill · NIH-11135316 · Data updated 2026-11-12
This study is looking at how a process called alternative splicing affects the way genes work in heart cells and other specialized cells, which could help us understand how to keep these cells healthy and functioning well.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | July 9, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $383,755 |
| NIH project number | 5R35GM152426-02 |
| Project ID | NIH-11135316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting cardiac muscle function or those interested in the genetic basis of heart health.
✕Less likely to help
Patients with non-cardiac conditions or those not affected by issues related to gene splicing may not benefit from this research.
What this research studies
This research investigates the role of alternative splicing in gene expression and its impact on cellular processes, particularly in specialized cells like cardiac muscle cells. The team will explore how splicing affects protein function, membrane trafficking, and cytoskeleton dynamics, which are crucial for maintaining cell health and function. By studying these mechanisms, the research aims to uncover how splicing influences organ physiology and compare these effects across different cell types, such as neurons.
Why it matters
Potential benefit: If successful, this research could lead to new insights into heart function and potential therapies for cardiac diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of alternative splicing in various cellular functions, indicating that this approach has potential for significant findings.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Giudice, Jimena — Univ of North Carolina Chapel Hill
- Study coordinator: Giudice, Jimena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.