Exploring how gene expression evolves across different species
Official title: Leveraging phylogenetic approaches to investigate the evolution of gene expression
Funded at University of Southern California · NIH-10894741 · Data updated 2026-11-12
This study is looking at how gene activity changes over time in different species, especially focusing on genes that help our immune system, to better understand how our genes work and evolve.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $398,500 |
| NIH project number | 5R35GM151348-02 |
| Project ID | NIH-10894741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to immune system function or genetic disorders that may be influenced by gene expression.
✕Less likely to help
Patients with conditions unrelated to gene expression or evolutionary biology may not receive direct benefits from this research.
What this research studies
This research investigates the evolution of gene expression by using phylogenetic approaches to analyze how gene expression changes across various species. The team will develop models to assess the dynamics of gene expression evolution and its relationship with genetic sequences, particularly focusing on the promoter regions of genes. Additionally, the research will delve into the evolution of Immunoglobulin genes, which are crucial for the immune response, by examining how these genes have adapted over time. This work aims to enhance our understanding of genomic function and its evolutionary processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of diseases and improve strategies for developing targeted therapies.
How similar studies have gone: Previous research using phylogenetic approaches has shown promise in understanding genetic evolution, indicating that this methodology could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Pennell, Matthew Wesley — University of Southern California
- Study coordinator: Pennell, Matthew Wesley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.