Exploring how gene expression evolves across different species
Leveraging phylogenetic approaches to investigate the evolution of gene expression
This study is looking at how gene activity changes over time in different species, especially focusing on genes that help our immune system, to better understand how our genes work and evolve.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10894741 on NIH RePORTER |
What this research studies
This research investigates the evolution of gene expression by using phylogenetic approaches to analyze how gene expression changes across various species. The team will develop models to assess the dynamics of gene expression evolution and its relationship with genetic sequences, particularly focusing on the promoter regions of genes. Additionally, the research will delve into the evolution of Immunoglobulin genes, which are crucial for the immune response, by examining how these genes have adapted over time. This work aims to enhance our understanding of genomic function and its evolutionary processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune system function or genetic disorders that may be influenced by gene expression.
Not a fit: Patients with conditions unrelated to gene expression or evolutionary biology may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of diseases and improve strategies for developing targeted therapies.
How similar studies have performed: Previous research using phylogenetic approaches has shown promise in understanding genetic evolution, indicating that this methodology could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Pennell, Matthew Wesley — University of Southern California
- Study coordinator: Pennell, Matthew Wesley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.