Exploring how diabetes affects heart function using human cells
Understanding Metabolic Interplay in a Human iPSC Model of Diabetic Cardiomyopathy
['FUNDING_FELLOWSHIP'] · STANFORD UNIVERSITY · NIH-11078663
This study is looking at how different heart cells interact in people with type 2 diabetes to better understand heart problems they might face, and it will also explore how certain diabetes medications could help protect the heart.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11078663 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between different heart cells in the context of diabetic cardiomyopathy, a condition that affects individuals with type 2 diabetes. By utilizing human-induced pluripotent stem cells (iPSCs), the study aims to understand the molecular and cellular mechanisms that lead to heart problems in diabetic patients. The research will also explore how certain diabetes medications, specifically sodium-glucose cotransporter-2 inhibitors, may protect the heart beyond their effects on blood sugar levels. This approach could provide insights into new therapeutic targets for improving heart health in people with diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may be experiencing heart-related issues.
Not a fit: Patients without diabetes or those with heart conditions unrelated to diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect the heart in patients with diabetes.
How similar studies have performed: Previous research has shown promising results using similar approaches to understand heart disease in diabetic patients, indicating potential for success in this study.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAUDAL, ARIANNE — STANFORD UNIVERSITY
- Study coordinator: CAUDAL, ARIANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, Atherosclerotic Cardiovascular Disease