Exploring how diabetes affects heart function using human cells
Official title: Understanding Metabolic Interplay in a Human iPSC Model of Diabetic Cardiomyopathy
Funded at Stanford University · NIH-11078663 · Data updated 2026-11-12
This study is looking at how different heart cells interact in people with type 2 diabetes to better understand heart problems they might face, and it will also explore how certain diabetes medications could help protect the heart.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32HL173968-02 |
| Project ID | NIH-11078663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may be experiencing heart-related issues.
✕Less likely to help
Patients without diabetes or those with heart conditions unrelated to diabetes may not benefit from this research.
What this research studies
This research investigates the complex interactions between different heart cells in the context of diabetic cardiomyopathy, a condition that affects individuals with type 2 diabetes. By utilizing human-induced pluripotent stem cells (iPSCs), the study aims to understand the molecular and cellular mechanisms that lead to heart problems in diabetic patients. The research will also explore how certain diabetes medications, specifically sodium-glucose cotransporter-2 inhibitors, may protect the heart beyond their effects on blood sugar levels. This approach could provide insights into new therapeutic targets for improving heart health in people with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect the heart in patients with diabetes.
How similar studies have gone: Previous research has shown promising results using similar approaches to understand heart disease in diabetic patients, indicating potential for success in this study.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Caudal, Arianne — Stanford University
- Study coordinator: Caudal, Arianne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.