Exploring how certain proteins trigger inflammation in the brain
Official title: Uncovering the role of extracellular condensates as triggers of neuroinflammation
Funded at Baylor College of Medicine · NIH-10910474 · Data updated 2026-11-12
This study is looking at how certain protein clumps in the brain might cause inflammation that worsens conditions like ALS and frontotemporal dementia, and it aims to understand how brain support cells react to these clumps, which could help find new ways to treat these diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,440,000 |
| NIH project number | 1DP2NS142714-01 |
| Project ID | NIH-10910474 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
✕Less likely to help
Patients with neurodegenerative diseases not related to inflammation or those without a diagnosis may not receive benefit from this research.
What this research studies
This research investigates the role of extracellular condensates, which are protein aggregates, in triggering neuroinflammation associated with neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The study aims to understand how glial cells, which are crucial for brain health, respond to these protein aggregates and contribute to disease progression. By examining the interactions between these proteins and the immune system, the research seeks to uncover new mechanisms of neuroinflammation that could lead to innovative treatment strategies. Patients may benefit from insights that could inform future therapies targeting neuroinflammatory processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating neurodegenerative diseases by targeting neuroinflammation.
How similar studies have gone: Previous research has shown promising results in understanding the role of neuroinflammation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Boeynaems, Steven — Baylor College of Medicine
- Study coordinator: Boeynaems, Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.