Exploring how certain genes in green algae produce multiple proteins from a single RNA strand
Official title: Uncovering the Function and Protein Subcellular Localization of Bicistronic Loci in Auxenochlorella protothecoides
Funded at University of California Berkeley · NIH-11067341 · Data updated 2026-11-12
This study is looking at how certain genes in a type of green algae can create multiple proteins from one piece of genetic material, which might help us learn more about similar processes in humans and could lead to better understanding of health and disease for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | April 1, 2025 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $45,965 |
| NIH project number | 1F31GM157804-01 |
| Project ID | NIH-11067341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals interested in genetic and cellular biology, particularly those affected by conditions related to protein function.
✕Less likely to help
Patients with conditions unrelated to genetic or cellular biology may not receive direct benefits from this research.
What this research studies
This research investigates the function and localization of specific genes in the green alga Auxenochlorella protothecoides that can produce multiple proteins from one RNA molecule. By utilizing advanced sequencing technologies and gene replacement methods, the study aims to uncover the roles of these proteins, many of which are conserved across eukaryotes, including humans. Patients may benefit from insights gained about these proteins, as they could have implications for understanding similar processes in human health and disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of protein functions that are relevant to human biology and disease mechanisms.
How similar studies have gone: Other research has shown success in understanding polycistronic gene expression in various organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Duenas, Marco Alonzo — University of California Berkeley
- Study coordinator: Duenas, Marco Alonzo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.