Exploring how brain stimulation affects brain network changes in humans
Investigating Network Plasticity Effects of Repetitive Brain Stimulation Following Invasive and Noninvasive Methods in Humans
['FUNDING_OTHER'] · UNIVERSITY OF IOWA · NIH-10880670
This study is looking at how certain brain stimulation techniques can change brain activity to help improve treatments for people with major depressive disorder, especially those who haven't found relief with standard therapies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10880670 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of repetitive brain stimulation techniques, such as transcranial magnetic stimulation (TMS), on brain network plasticity using advanced intracranial electroencephalography (iEEG). By analyzing how these stimulation methods alter brain excitability, the study aims to improve therapeutic outcomes for neuropsychiatric disorders, particularly major depressive disorder. Patients may undergo either invasive or noninvasive stimulation methods while their brain activity is closely monitored to gain insights into optimal stimulation parameters. The goal is to enhance our understanding of brain function and improve treatment efficacy for those who do not respond to traditional therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with medication-refractory major depressive disorder or other neuropsychiatric conditions who are seeking alternative treatment options.
Not a fit: Patients with stable conditions who are not experiencing significant symptoms or those who have not been diagnosed with neuropsychiatric disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with neuropsychiatric disorders, particularly those who have not benefited from existing therapies.
How similar studies have performed: Previous research has shown promising results with TMS in treating depression, but this approach aims to refine and enhance those methods through a novel invasive technique.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRAPP, NICHOLAS THOMAS — UNIVERSITY OF IOWA
- Study coordinator: TRAPP, NICHOLAS THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders, Disease remission