Exploring how blood vessel damage affects breathing difficulties in patients with ARDS
Official title: Investigating the Role of Vascular Injury and Physiologic Dead Space in the Acute Respiratory Distress Syndrome - Supplement
Funded at University of California Los Angeles · NIH-11271544 · Data updated 2026-11-12
This study is looking at how damage to blood vessels affects the seriousness of lung problems in people with Acute Respiratory Distress Syndrome (ARDS), and it hopes to find clues in the blood that can help doctors give better, more tailored treatments to patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 15, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,600 |
| NIH project number | 3K23HL165149-02S1 |
| Project ID | NIH-11271544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Acute Respiratory Distress Syndrome.
✕Less likely to help
Patients with chronic respiratory conditions unrelated to ARDS may not benefit from this research.
What this research studies
This research investigates the impact of vascular injury on the severity of Acute Respiratory Distress Syndrome (ARDS). It aims to identify biological markers in the blood that could indicate how severe a patient's lung condition is. By analyzing large datasets and using advanced techniques like transcriptomic analysis, the study seeks to improve understanding of ARDS and its outcomes. Patients may benefit from more personalized treatment approaches based on their specific biological responses.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients suffering from ARDS.
How similar studies have gone: Previous research has shown promise in understanding ARDS through similar biological and clinical approaches, indicating potential for success in this area.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Costa Monteiro, Ana Carolina — University of California Los Angeles
- Study coordinator: Costa Monteiro, Ana Carolina
Related research
Other NIH-funded projects on the same topics.
-
Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
-
Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
-
PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.