Exploring how blood vessel damage affects breathing difficulties in patients with acute respiratory distress syndrome.
Official title: Investigating the Role of Vascular Injury and Physiologic Dead Space in the Acute Respiratory Distress Syndrome
Funded at University of California Los Angeles · NIH-11004968 · Data updated 2026-11-12
This study is looking at how damage to blood vessels affects breathing problems in people with acute respiratory distress syndrome (ARDS) and aims to find better ways to treat this serious condition by checking certain blood markers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $181,980 |
| NIH project number | 5K23HL165149-02 |
| Project ID | NIH-11004968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome.
✕Less likely to help
Patients with chronic respiratory conditions unrelated to acute respiratory distress syndrome may not benefit from this research.
What this research studies
This research investigates the role of vascular injury in acute respiratory distress syndrome (ARDS), a serious condition that affects breathing. The project aims to understand how damage to blood vessels contributes to lung dysfunction and worsens patient outcomes. By measuring specific blood markers, the research seeks to assess the severity of pulmonary disease and improve treatment strategies. The principal investigator, Dr. Ana Monteiro, will utilize advanced techniques in data analysis and transcriptomics to enhance understanding of ARDS.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options for patients suffering from acute respiratory distress syndrome.
How similar studies have gone: Previous research has shown promising results in understanding vascular injury's role in respiratory conditions, indicating that this approach has potential for significant insights.
Where this research is happening
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University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Costa Monteiro, Ana Carolina — University of California Los Angeles
- Study coordinator: Costa Monteiro, Ana Carolina
Related research
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This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
-
Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
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PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.