Exploring how biological clocks in cells maintain stability
Official title: Understanding the robustness of cell cycles
Funded at University of Michigan at Ann Arbor · NIH-11038023 · Data updated 2026-11-12
This study is looking at how natural rhythms in our bodies, like those that control cell division and heartbeats, work and stay steady even when things around them change, which could help people understand and treat conditions like cancer or insomnia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $268,723 |
| NIH project number | 5R01GM144584-03 |
| Project ID | NIH-11038023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by conditions related to biological oscillators, such as cancer or sleep disorders.
✕Less likely to help
Patients with conditions unrelated to biological oscillators may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms behind biological oscillators, which are crucial for processes like cell division and heartbeats. By using a combination of computational analysis and experimental methods, the study aims to understand how these oscillators can remain stable despite changes in their environment. Patients may benefit from insights gained about how disruptions in these oscillators can lead to diseases such as cancer or insomnia. The research employs innovative techniques, including a droplet-based microfluidic system to simulate cell cycles.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to dysfunctional biological oscillators.
How similar studies have gone: Other research has shown promising results in understanding biological oscillators, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Yang, Qiong — University of Michigan at Ann Arbor
- Study coordinator: Yang, Qiong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.