Exploring how bacteria influence cancer development and treatment.
Interrogating the Role of Bacterial Methyl-modifying Enzymes in Pathoadaptation and Host Epigenetic Interference in Cancer
This study is looking at how certain bacteria might change our genes and help cancer grow, especially in people with colorectal cancer, to find new ways to prevent and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10999811 on NIH RePORTER |
What this research studies
This research investigates the role of specific bacterial enzymes in the development of cancer, particularly how they may alter the human genome and contribute to tumor growth. By studying the interaction between bacteria and cancer cells in the tumor microenvironment, the researchers aim to identify potential therapeutic targets for cancer prevention and treatment. The study utilizes advanced genetic and microbiological techniques to analyze bacterial strains found in colorectal cancer patients, focusing on their impact on cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with colorectal cancer or those at high risk for developing this type of cancer.
Not a fit: Patients with cancers unrelated to bacterial influences or those who do not have colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cancer by targeting bacterial influences on tumor development.
How similar studies have performed: Previous studies have shown promising results in understanding the relationship between the microbiome and cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Johnston, Christopher D — University of Tx Md Anderson Can Ctr
- Study coordinator: Johnston, Christopher D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.