Exploring how arginine metabolism affects antibiotic treatment success in Staphylococcus aureus infections
Understanding the role of arginine metabolism in antibiotic treatment failure during Staphylococcus aureus infections
This study is looking into why some infections caused by a tough bacteria called Staphylococcus aureus don’t get better with antibiotics, and it’s especially interested in how a key nutrient called arginine helps the bacteria survive, which could help doctors find better ways to treat these infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10948478 on NIH RePORTER |
What this research studies
This research investigates the reasons behind antibiotic treatment failures in infections caused by Staphylococcus aureus, a common and dangerous bacterium. It focuses on understanding how the metabolism of arginine, an important amino acid, influences the bacteria's ability to survive despite antibiotic treatment. By using advanced genetic and proteomic techniques, the study aims to uncover the mechanisms of antibiotic tolerance in these infections. This knowledge could lead to the development of new treatment strategies that improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with Staphylococcus aureus infections, particularly those experiencing treatment failures.
Not a fit: Patients with infections caused by other types of bacteria or those who do not have antibiotic treatment failures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from serious Staphylococcus aureus infections.
How similar studies have performed: Previous research has shown promising results in understanding antibiotic tolerance mechanisms, but this specific focus on arginine metabolism is relatively novel.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Freiberg, Jeffrey Alexander — Vanderbilt University Medical Center
- Study coordinator: Freiberg, Jeffrey Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.