Exploring how antibiotics prevent the joining of ribosomal subunits
Official title: Understanding Mechanisms of Antibiotic Inhibition of Ribosomal Subunit Joining
Funded at University of Arkansas at Fayetteville · NIH-10876053 · Data updated 2026-11-12
This study is looking at how regular antibiotics stop bacteria from making proteins by interfering with their ribosomes, and it aims to find new ways to create antibiotics that can fight off tough, resistant bacteria.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $403,423 |
| NIH project number | 1R15GM151696-01A1 |
| Project ID | NIH-10876053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from bacterial infections that are resistant to current antibiotic treatments.
✕Less likely to help
Patients with viral infections or those who do not have antibiotic-resistant bacterial infections may not benefit from this research.
What this research studies
This research investigates how conventional antibiotics work to inhibit the formation of ribosomes, which are essential for protein synthesis in bacteria. By focusing on the process of ribosome assembly, the study aims to uncover the molecular mechanisms that antibiotics target to prevent bacterial growth. The research utilizes advanced techniques like cryo-electron microscopy to analyze the interactions between antibiotics and ribosomal subunits. Understanding these mechanisms could lead to the development of new antibiotics that are effective against resistant bacterial strains.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antibiotics that effectively combat antibiotic-resistant bacterial infections.
How similar studies have gone: Previous research has shown promise in understanding antibiotic mechanisms, but this specific focus on ribosomal subunit joining is relatively novel.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Girodat, Dylan Joseph — University of Arkansas at Fayetteville
- Study coordinator: Girodat, Dylan Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.