Exploring how a specific protein affects brain cell development and function
Official title: Investigating the role of diazepam binding inhibitor (DBI) in astrocytes and neural circuit maturation
Funded at Oregon Health & Science University · NIH-11015900 · Data updated 2026-11-12
This study is looking at how a protein called DBI in brain support cells affects the way our brain develops and responds to anxiety medications, with the goal of finding better treatments for anxiety disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | February 1, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $55,304 |
| NIH project number | 5F32NS129591-03 |
| Project ID | NIH-11015900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing anxiety disorders or related neurological conditions.
✕Less likely to help
Patients who do not have anxiety disorders or related conditions may not benefit from this research.
What this research studies
This research investigates the role of diazepam binding inhibitor (DBI) in astrocytes, which are essential cells in the brain that support neuronal development and function. The study aims to understand how DBI influences the maturation of neural circuits and the brain's response to commonly prescribed anxiety medications. By examining the interactions between DBI and various receptors in astrocytes, researchers hope to uncover mechanisms that could lead to improved treatments for anxiety disorders and related conditions. The approach includes both laboratory experiments and analysis of brain cell behavior in response to DBI.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for anxiety disorders and improve the effectiveness of existing medications.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocytes in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Heo, Dongeun — Oregon Health & Science University
- Study coordinator: Heo, Dongeun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.