Exploring how a specific gene mutation affects the gut-brain connection in Parkinson's disease.
Understanding the role of LRRK2 G2019S-mediated gut-brain axis in the pathogenesis of Parkinson's disease
['FUNDING_R21'] · UNIVERSITY OF IOWA · NIH-10584197
This study is looking at how a specific gene mutation related to Parkinson's disease might affect gut health and inflammation, with the hope of finding new ways to prevent and treat the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10584197 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the LRRK2 G2019S gene mutation in the development of Parkinson's disease (PD) by examining the gut-brain axis. The study aims to understand how this mutation influences inflammation and gut health, which may contribute to the onset of PD symptoms. Researchers will utilize animal models and human serum analysis to identify potential biomarkers and mechanisms involved in the disease process. By focusing on the relationship between gut health and PD, the research seeks to uncover new insights that could lead to improved prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a family history of Parkinson's disease or those who are asymptomatic carriers of the LRRK2 G2019S mutation.
Not a fit: Patients without the LRRK2 G2019S mutation or those with advanced Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapeutic approaches for Parkinson's disease, particularly for those with the LRRK2 G2019S mutation.
How similar studies have performed: Previous studies have shown promising results in understanding the gut-brain connection in Parkinson's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANG, ZIZHEN — UNIVERSITY OF IOWA
- Study coordinator: KANG, ZIZHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, bacteria infection, bacterial disease, Disease, Disorder