Exploring how 3D genome structures affect cancer treatment responses
Official title: Bridging the gap: joint modeling of single-cell 1D and 3D genomics
Funded at University of Tx Md Anderson Can Ctr · NIH-11141974 · Data updated 2026-11-12
This study is looking at how the way our genes are organized in 3D affects how well CAR-T cell therapy works for patients with acute lymphoblastic leukemia, with the goal of finding ways to make treatments more personalized and effective for each individual.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 2, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $248,999 |
| NIH project number | 4R00HG012797-03 |
| Project ID | NIH-11141974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute lymphoblastic leukemia who are considering or undergoing CAR-T cell therapy.
✕Less likely to help
Patients with other types of cancers or those not eligible for CAR-T cell therapy may not receive benefits from this research.
What this research studies
This research investigates the relationship between three-dimensional genome structures and gene regulation in individual cells, particularly in the context of CAR-T cell therapy for acute lymphoblastic leukemia. By developing new scoring systems and machine learning models, the study aims to analyze how variations in gene regulation can influence patient responses to treatment. The approach combines advanced single-cell technologies to provide insights into the epigenomic features and chromatin interactions of cells, potentially leading to more personalized cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved CAR-T cell therapies by tailoring treatments based on individual genetic and epigenetic profiles.
How similar studies have gone: Previous research has shown promise in using single-cell technologies to enhance understanding of cancer biology, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Zheng, Ye — University of Tx Md Anderson Can Ctr
- Study coordinator: Zheng, Ye
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.